Exeter City will play against Plymouth Argyle and Yeovil Town in the group stages of the 2017/18 Checkatrade Trophy.
The Grecians, who have been placed into group D of the southern section of the draw, will also face one other category one club at home.
This could be any of the following teams: Brighton & Hove Albion, Chelsea, Fulham, Reading, Southampton, Swansea City, Tottenham Hotspur or West Ham United.
The dates for all three matches have yet to be confirmed and the venues for the games against Yeovil Town and Plymouth Argyle are also still to be finalised. The EFL will release those details on Wednesday.